Methylcobalamin – 500 mcg
Gabapentin – 300 mg
Each box contain 3 Alu-Alu strips of 10 tablets
Abantin – M Tablet contains methylcobalamin and gabapentin.
Methylcobalamin is a form of vitaminB12. It is a cobalamin which differs from cyanocobalamin. The cyanide group is replaced by methyl group in methylcobalamin. Octahedral cobalt III is present in the centre.
Gabapentin is mainly a antiepileptic drug which produces its effect on chemical and nerves in the body which causes seizers and pain in the body.
- Megaloblastic anemia caused by vitB12 deficiency
- Peripheral neuropathy
- Diabetic neuropathy
- Neuropathic disorder
- Bipolar disorder
The drug after oral administration is absorbed in the intestine. The transformation of the drug to the gut is mainly through an receptor.
It is the active form of vitamin B12 which a water soluble vitamin. It functions as to transfer methyl group for the regeneration of methionine from homocysteine. It acts as a cofactor for enzyme methionin synthase. In cases of anemia it causes the production of erythrocytes by nucleic acid synthesis in bone marrow.
The drug is well absorbed in the body with peak concentration achieved after 3hrs.
After oral administration it is well distributed
The drug is excreted through urine.
Its bioavailability is inversely proportional to dose. As dose increases bioavailability decreases. Co-administration of the food rarely effects the bioavailability of the drug
Drug rarely bounds to plasma protein. The apparent volume of distribution of the drug is 150mg.
The drug is excreted through kidney in unchanged form.
- Hypersensitivity to any of the ingredient
- Difficulty in operating machinery
- Suicidal behaviour