Aklonac MR Tablet2018-11-11T17:03:13+05:30
Aklonac-mr-soltech-product

Aceclofenac –  100 mg

Paracetamol –  325 mg

Chlorzoxazone  –  250 mg

Each box contain 10 Blister strips of 10 tablets

Aclonac MR contains Aceclofenac, Paracetamol and Chlorzoxazone.

Aceclofenac is a phenylacetic acid derivative which produces its action on inflammatory mediators. It is a glycolic acid ester of diclofenac.

Paracetamol is also known as acetaminophen and is widely used as over the counteranalgesic and anti-pyretic. It is a mild analgesic which causes relief in mild headaches and other aches and pains. In combination with other drugs like opioid analgesic,    paracetamol is used in the management of post surgical pain and severe pain.

Chlorzoxazone  is centrally acting muscle relaxant which reduces pain and discomfort of the pain. It mainly acts on spinal cord by depressing reflexes.

  • Treatment of muscle spasm
  • Pain and discomfort
  • Acute pain
  • Analgesic
  • Anti-pyretic
  • Migraine headaches
  • Ankylosing spondylitis
  • Rheumatoid arthritis
  • Osteoarthritis
  • Migraine
  • Headache
  • Fibromyalgia

Aceclofenac

It is a NSAID which produces its action by blocking COX-1 which is involved in inflammatory processes. This inflammatory mediators produces response to any injury    and cause pain and swelling. It is a glycolic acid ester of diclofenac.

Paracetamol

It inhibits the synthesis of prostaglandin synthesis by competing with arachidonic acid for the active site of COX.

Chlorzoxazone

It prevents the release of histamine and inhibits degranulation of mast cells. It also reduces the inflammatory leukotrienes. It produces its action by inhibiting calcium and potassium influx which causes neuronal inhibition.

Aceclofenac

Absorption

After oral administration it is well absorbed in the body.

Distribution

About 99.7% of the drug is bound to plasma protein. It produces its action  by concentrating in synovial fluid. The drug is metabolized in liver as 4-hydroxyaceclofenac.

Excretion

It is excreted as conjugated metabolites through urine.

Paracetamol

Absorption

It has rapid and complete absorption

           

 

Distribution

The protein binding of the drug is about 25%, it undergoes glucuronidation in liver.

Excretion

About 80% of acetaminophen is excreted in the urine after conjugation and about 3% of the drug          is excreted unchanged.

Chlorzoxazone

Absorption

After administration the drug is well absorbed in the body. Chlorzoxazone acts primarily at the level of the spinal cord and subcortical areas of the brain where it inhibits multisynaptic reflex arcs

Distribution

It is well distributed in the body with the blood serum levels attained within first 30 min and peak levels achieved in 1 to 2 hrs after oral administration.

Excretion

The drug is excreted in conjugated form as the glucuronide form in urine.

  • Hypersensitivity to any of the component present in the drug
  • Patients with asthma, bronchospasm or acute rhinitis
  • Renal impairment
  • Patient with the history of peptic ulcer
  • Liver Failure
  • Liver Problems
  • Serious Kidney Problems
  • Contraindicated in patients with intolerance to the drug
  • Cautiously used in epileptic patients and patients with convulsions
  • Lower dose should be used in patients with diarrhea
  • Ulcerative colitis
  • Crohn’s disease
  • Elderly Patients
  • Any allergies
  • Liver disease
  • Alcohol abuse
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