Aceclofenac – 100 mg
Paracetamol – 325 mg
Each box contain 10 Blister strips of 10 tablets
Aklonac-P contains Aceclofenac and Paracetamol
Aceclofenac is a phenylacetic acid derivative which produces its action on inflammatory mediators. It is a glycolic acid ester of diclofenac.
Paracetamol is also known as acetaminophen and is widely used as over the counter analgesic and anti-pyretic. It is a mild analgesic which causes relief in mild headaches and other aches and pains. In combination with other drugs like opioid analgesic, paracetamol is used in the management of post surgical pain and severe pain.
- Acute pain
- Migraine headaches
- Ankylosing spondylitis
- Rheumatoid arthritis
Dosage: Two tablet once a day
It is a NSAID which produces its action by blocking COX-1 which is involved in inflammatory processes. This inflammatory mediators produces response to any injury and cause pain and swelling. It is a glycolic acid ester of diclofenac.
It inhibits the synthesis of prostaglandin synthesis by competing with arachidonic acid for the active site of COX.
After oral administration it is well absorbed in the body.
About 99.7% of the drug is bound to plasma protein. It produces its action by concentrating in synovial fluid. The drug is metabolized in liver as 4-hydroxyaceclofenac.
It is excreted as conjugated metabolites through urine.
It has rapid and complete absorption
The protein binding of the drug is about 25%, it undergoes glucuronidation in liver.
About 80% of acetaminophen is excreted in the urine after conjugation and about 3% of the drug is excreted unchanged.
- Hypersensitivity to any of the component present in the drug
- Patients with asthma, bronchospasm or acute rhinitis
- Renal impairment
- Patient with the history of peptic ulcer
- Liver Failure
- Liver Problems
- Serious Kidney Problems
- Cautiously used in epileptic patients and patients with convulsions
- Lower dose should be used in patients with diarrhea
- Ulcerative colitis
- Crohn’s disease
- Elderly Patients
- Any allergies
- Liver disease
- Alcohol abuse