Aceclofenac  –  100 mg

Paracetamol  –  325 mg

Each box contain 10 Blister strips of 10 tablets

Aklonac-P contains Aceclofenac and Paracetamol

Aceclofenac is a phenylacetic acid derivative which produces its action on inflammatory mediators. It is a glycolic acid ester of diclofenac. 

Paracetamol is also known as acetaminophen and is widely used as over the counter analgesic and anti-pyretic. It is a mild analgesic which causes relief in mild headaches and other aches and pains. In combination with other drugs like opioid analgesic, paracetamol is used in the management of post surgical pain and severe pain.

• Acute pain
• Analgesic
• Anti-pyretic
• Migraine headaches
• Ankylosing spondylitis
• Rheumatoid arthritis
• Osteoarthritis
• Migraine
• Headache
• Fibromyalgia

Dosage: Two tablet once a day

Aceclofenac

 It is a NSAID which produces its action by blocking COX-1 which is involved in       inflammatory processes. This inflammatory mediators produces response to any injury        and cause pain and swelling. It is a glycolic acid ester of diclofenac. 

 Paracetamol

 It inhibits the synthesis of prostaglandin synthesis by competing with arachidonic acid      for the active site of COX.

Aceclofenac

            Absorption

            After oral administration it is well absorbed in the body.

            Distribution

            About 99.7% of the drug is bound to plasma protein. It produces its action  by       concentrating in synovial fluid. The drug is metabolized in liver as 4-hydroxyaceclofenac.

            Excretion

            It is excreted as conjugated metabolites through urine.

            Paracetamol

            Absorption

            It has rapid and complete absorption

            Distribution

            The protein binding of the drug is about 25%, it undergoes glucuronidation in liver.

            Excretion

            About 80% of acetaminophen is excreted in the urine after conjugation and about 3% of the drug is excreted unchanged.

• Hypersensitivity to any of the component present in the drug
• Patients with asthma, bronchospasm or acute rhinitis
• Renal impairment
• Patient with the history of peptic ulcer
• Liver Failure
• Liver Problems
• Serious Kidney Problems

• Cautiously used in epileptic patients and patients with convulsions
• Lower dose should be used in patients with diarrhea
• Ulcerative colitis
• Crohn’s disease
• Elderly Patients
• Any allergies
• Liver disease
• Alcohol abuse