Aklonac SP Tablet2018-11-11T17:18:41+00:00
Aklonac-SP-soltech-product

Aceclofenac    –   100 mg

Paracetamol  –   325 mg

Serratiopeptidase  –  15 mg

Each box contain 10 Blister strips of 10 tablets

Aklonac-SP is a combination of serratiopeptidase, aceclofenac and paracetamol.

Serratiopeptidase

It is a proteolytic enzyme which is produced by enterobacterium serratia. This is present in silk worm intestine and allows the emerging moth to dissolve its cocoon.

Aceclofenac is a phenylacetic acid derivative which produces its action on inflammatory mediators. It is a glycolic acid ester of diclofenac.

Paracetamol

It is also known as acetaminophen and is widely used as over the counter analgesic and anti-pyretic. It is a mild analgesic which causes relief in mild headaches and other aches and pains. In combination with other drugs like opioid analgesic, paracetamol is used in the management of post surgical pain and severe pain.

  • Fever
  • Pain
  • Inflammation
  • To promote antibiotic to the site of action
  • To promote lysis and discharge of sputum and pus
  • Bronchitis
  • Sinusitis
  • Cough
  • Laryngitis
  • Gout
  • Osteoarthritis
  • Migraine
  • Headache
  • Fibromyalgia

Serratiopeptidase

It binds to alpha-2 microglobulin which is present in blood which masks the antigenicity. After this it is slowly transferred to the site of inflammation. It causes hydrolyzation of bradykinin, histamine, serotoxin which are responsible for edema. It also causes reduction in microcirculation and expectoration of sputum which makes to have anti-inflammatory property.

Aceclofenac

It is a NSAID which produces its action by blocking COX-1 which is involved in inflammatory processes. This inflammatory mediators produces response to any injury and cause pain and swelling. It is a glycolic acid ester of diclofenac.

Paracetamol

It inhibits the synthesis of prostaglandin synthesis by competing with arachidonic acid for the active site of COX.

Serratiopeptidase  

Absorption

The drug is orally absorbed

Distribution

It is well distributed in blood stream

Excretion

The excretion of the drug is through urine and bile

Aceclofenac

Absorption

After oral administration it is well absorbed in the body.

Distribution

About 99.7% of the drug is bound to plasma protein. It produces its action  by concentrating in synovial fluid. The drug is metabolized in liver as 4-hydroxyaceclofenac.

Excretion

It is excreted as conjugated metabolites through urine.

Paracetamol

Absorption

It has rapid and complete absorption

Distribution

The protein binding of the drug is about 25%, it undergoes glucuronidation in liver.

Excretion

About 80% of acetaminophen is excreted in the urine after conjugation and about 3% of the drug is excreted unchanged.

  • Hypersensitivity to any ingredient of the drug
  • Blood coagulation disorder
  • Third trimester of pregnancy
  • Patients with GI bleeding
  • Patients with pre-existing hepatic porphyria
  • Liver Failure
  • Liver Problems
  • Serious Kidney Problems
  • Hepatic failure
  • Renal failure
  • Anemia
  • Pre-existing asthma
  • Any allergies
  • Liver disease
  • Alcohol abuse
  • Chewable tablet may contain sugar or aspartame should not be used in diabetic  patients