Aceclofenac – 100 mg
Paracetamol – 325 mg
Serratiopeptidase – 15 mg
Each box contain 10 Blister strips of 10 tablets
Aklonac-SP is a combination of serratiopeptidase, aceclofenac and paracetamol.
It is a proteolytic enzyme which is produced by enterobacterium serratia. This is present in silk worm intestine and allows the emerging moth to dissolve its cocoon.
Aceclofenac is a phenylacetic acid derivative which produces its action on inflammatory mediators. It is a glycolic acid ester of diclofenac.
It is also known as acetaminophen and is widely used as over the counter analgesic and anti-pyretic. It is a mild analgesic which causes relief in mild headaches and other aches and pains. In combination with other drugs like opioid analgesic, paracetamol is used in the management of post surgical pain and severe pain.
- To promote antibiotic to the site of action
- To promote lysis and discharge of sputum and pus
It binds to alpha-2 microglobulin which is present in blood which masks the antigenicity. After this it is slowly transferred to the site of inflammation. It causes hydrolyzation of bradykinin, histamine, serotoxin which are responsible for edema. It also causes reduction in microcirculation and expectoration of sputum which makes to have anti-inflammatory property.
It is a NSAID which produces its action by blocking COX-1 which is involved in inflammatory processes. This inflammatory mediators produces response to any injury and cause pain and swelling. It is a glycolic acid ester of diclofenac.
It inhibits the synthesis of prostaglandin synthesis by competing with arachidonic acid for the active site of COX.
The drug is orally absorbed
It is well distributed in blood stream
The excretion of the drug is through urine and bile
After oral administration it is well absorbed in the body.
About 99.7% of the drug is bound to plasma protein. It produces its action by concentrating in synovial fluid. The drug is metabolized in liver as 4-hydroxyaceclofenac.
It is excreted as conjugated metabolites through urine.
It has rapid and complete absorption
The protein binding of the drug is about 25%, it undergoes glucuronidation in liver.
About 80% of acetaminophen is excreted in the urine after conjugation and about 3% of the drug is excreted unchanged.
- Hypersensitivity to any ingredient of the drug
- Blood coagulation disorder
- Third trimester of pregnancy
- Patients with GI bleeding
- Patients with pre-existing hepatic porphyria
- Liver Failure
- Liver Problems
- Serious Kidney Problems
- Hepatic failure
- Renal failure
- Pre-existing asthma
- Any allergies
- Liver disease
- Alcohol abuse
- Chewable tablet may contain sugar or aspartame should not be used in diabetic patients