Contrapore 200 Capsule2018-11-11T13:01:43+05:30
contrapore 200-soltech-product
Itraconazole – 200 mg

Each box contain 5 Blister strips of 6 tablets

Contrapore 200 Capsules contains Itraconazole. It is a triazole antifungal drug which has broad spectrum of activity than fluconazole.

  • Fungal infections
  • Blastomycosis
  • Histoplasmosis
  • Aspergillosis

Cantrapore 200 capsules produces its action by interacting with cytochrome P450 which inhibits the conversion of  lanosterol to ergosterol. It is the required necessary component of fungal cell wall. As the destruction of the cell wall causes leakage of the contents of the cell. It also causes inhibition of purine uptake and impairs the phospholipids synthesis required by the fungal cell.

Absorption

After oral administration the bioavailability of the drug is 55%. The drug produces its maximal effect by when taken with full meals.

Distribution

About 99.8% of the drug is bound to plasma protein. The volume of distribution of the drug is about 796 ± 185 L. The drug is mainly metabolized by liver.

Excretion

The inactive metabolites of the drug is excreted in urine and feces.

  • Not to be taken by the patients with the history of CHF
  • Should not be used in patients with cardiac problem
  • Co-administration of certain drug can affect the action of drug
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