Nimesulide – 100 mg
Each box contain 10 Blister strips of 10 tablets
Coxulide-MD contains nimesulide which is in mouth dissolving form of tablet. Nimesulide is selective COX-2 NSAID which possesses analgesic and antipyretic properties. It is mainly used for the treatment of acute pain, osteoarthritis and primary dysmenorrhoea in adolescents.
- Painful inflammatory conditions
- Back pain
- Postoperative pain
It produces its therapeutic effect by targeting the key mediators of inflammatory process which includes COX-2 mediated prostaglandins, free radicals, histamine and proteolytic enzymes.
After oral administration it is rapidly adsorbed by the body.
It undergoes extensive biotransformation to 4-hydroxynimesulide which is a biologically active form of the drug. The drug produces its pharmacological effect within 15mins from the drug intake. The protein binding of the drug is more than 97.5%
The half life of the drug is 1.8–4.7 hours. About 50% of the drug is excreted through kidney and 29% in feces.
- Severe hepatic disease
- Severe kidney disease
- Bleeding disorder
- Stomach problems
- Gastrointestinal ulcers
- Diabetes mellitus
- Alcohol abuse
- Crohn’s disease
- Gastric ulcer