Coxulide – P Tablet2018-11-11T17:31:50+05:30
coxulide-p-soltech-product

Nimesulide   –  100 mg

Paracetamol   –   325 mg

Each box contain 10 Blister strips of 10 tablets

Coxulide- P contains nimesulide and paracetamol.

Nimesulide

It is selective COX-2 NSAID which possesses analgesic and antipyretic properties. It is mainly used for the treatment of acute pain, osteoarthritis and primary dysmenorrhoea in adolescents.

Paracetamol

It is also known as acetaminophen and is widely used as over the counter analgesic and anti-pyretic. It is a mild analgesic which causes relief in mild headaches and other aches and pains. In combination with other drugs like opioid analgesic, paracetamol is used in the management of post surgical pain and severe pain.

  • Acute pain
  • Treatment of osteoarthritis
  • Dysmenorrhoea in adolescents
  • Analgesic and antipyretic

Nimesulide

It produces its therapeutic effect by targeting the key mediators of inflammatory process which includes COX-2 mediated prostaglandins, free radicals, histamine and proteolytic enzymes.

Paracetamol

It inhibits the synthesis of prostaglandin synthesis by competing with arachidonic acid for the active site of COX.

Paracetamol

Absorption

It has rapid and complete absorption

Distribution

The protein binding of the drug is about 25%, it undergoes glucuronidation in liver.

Excretion

About 80% of acetaminophen is excreted in the urine after conjugation and about 3% of the drug is excreted unchanged.

Nimesulide

Absorption

After oral administration it is rapidly adsorbed by the body.

Distribution

It undergoes extensive biotransformation to 4-hydroxynimesulide which is a biologically active form of the drug. The drug produces its pharmacological effect within 15mins from the drug intake. The protein binding of the drug is more than 97.5%

Excretion

The half life of the drug is 1.8–4.7 hours. About 50% of the drug is excreted through kidney and 29% in feces.

  • Hepatic and renal impairment
  • Children under the 12yrs of age
  • In pregnant and lactating mothers
  • Patients with gastric bleeding, ulcer
  • Severe hepatic disease
  • Severe kidney disease
  • Bleeding disorder
  • Hypersensitivity
  •  Stomach problems
  • Gastrointestinal ulcers
  • Patients with the history of stomach problem
  • High blood pressure
  • Fluid retention
  • Pregnancy and breast feeding mothers.
  •  Diabetes mellitus
  • Alcohol abuse
  • Colitis
  •  Crohn’s disease
  • Diverticulitis
  • Gastric ulcer
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