Cefpodoxime – 200 mg
Each box contain 10 Alu-Alu strips of 10 tablets
Cefpodoxime is a semi-synthetic antibiotic belonging to cephalosporin class meant for oral administration. It is mainly produces action against gram positive and gram negative bacteria organisms. It mainly produces action against Pseudomonas aeruginosa, Enterococcus and Bacteroides fragilis.
- Used for the treatment of mild to moderate infections
- Acute otitis media caused by Streptococcus pneumonia, S.pyrogens, Haemophilus influenza etc.
- Pharyngitis and tonsillitis caused by Streptococcus pyrogenes
- Community acquired pneumonia
- Chronic bronchitis of bacterial exacerbation
- Urethral and cervical gonorrhea
- Ano-rectalinfections caused by Neisseria gonorrhea
- Skin and structure infections caused by Staphylococcus pyrogens
Cefpodoxime is active against both gram positive and gram negative bacteria. It is steady in presence of beta-lactamase enzyme. It causes inhibition of cell wall synthesis and restraining the final step of transpeptidation of peptidoglycon synthesis in cell wall. Inhibition of cell wall synthesis occurs as cefpodoxime binds to PBPs 3.
Absorption
After administration it is absorbed from the gastro-intestinal tract. The drug produces dose dependent response. In fasting subjects the drug gets de-esterified to its active metabolite.
Distribution
It is widely distributed into the tissue fluids of the body. The protein binding of the drug in the serum is about 22-33% and from plasma it is about 21-29% .The drug is de-esterified to its active metabolite.
Excretion
About 29-33% of the drug is excreted through urine in 12hrs in unchanged form.
- High dose produces side-effects
- In severe toxicity can occur with overdose
- Prolong use of cefpodoxime causes severe toxicity which can removed by hemo-dialysis or peritoneal dialysis
- Patients with reduced renal output or renal insufficiency can increases the concentration of drug in serum
- Teratogenicity occurs in pregnant patients.
- Not safe for pediatric patients
- To be safely used in nursing mother as it gets also transferred to human milk
