Mefanamic acid – 500 mg
Paracetamol – 325 mg
Each box contain 10 Blister strips of 10 tablets
Nefmic Forte contains Mefenamic acid and Paracetamol.
It is a NSAID which is used for the treatment of pain. It decreases the swelling in inflammation and also uterine contractions. It also inhibits PG synthesis.
It is also known as acetaminophen and is widely used as over the counter analgesic and anti-pyretic. It is a mild analgesic which causes relief in mild headaches and other aches and pains. In combination with other drugs like opioid analgesic, paracetamol is used in the management of post surgical pain and severe pain.
- Potent analgesic
- Acute pain
- Smooth muscle spasm
- It also blocks the substances which causes inflammation
It produces its pharmacological action by binding to prostaglandin synthetase receptors COX-1 and COX-2 and causes the inhibition of its action. As these plays a major role in causing inflammation.
It inhibits the synthesis of prostaglandin synthesis by competing with arachidonic acid for the active site of COX.
It is rapidly absorbed after oral administration. The mean peak levels of mefenamic acid are ranging from 10-20mcg/ml3. Co-administration of mefenamic with antacid increases the absorption rate of magnesium hydroxide.
It is well distributed in the body with 90% of the drug is bound to plasma protein. The volume of distribution of the drug is 1.06 l/kg. It is metabolized by liver cytochrome P450 enzyme CYP2C9 to 3-hydroxymethyl mefenamic acid (Metabolite I).
About 52% of the drug is excreted in urine as glucuronides of mefenamic acid. About 20% of the drug is excreted through urine.
It has rapid and complete absorption
The protein binding of the drug is about 25%, it undergoes glucuronidation in liver.
About 80% of acetaminophen is excreted in the urine after conjugation and about 3% of the drug is excreted unchanged.
- Mefenamic acid should not be administered to the patients with asthma, urticaria or allergic reactions
- Pre-operative pain in coronary artery bypass graft (CABG) surgery
- Hepatic and renal impairment
- Complicated acute abdominal conditions
- Renal disease
- Hepatic disease
- Prolong half life can cause difficulty in achieving steady state of drug in body.
- Patients with pregnancy and lactation
- Cannot be substituted for corticosteroid therapy