Mefanamic acid – 250 mg
Dicyclomine Hydrochloride – 10 mg
Each box contain 10 Blister strips of 10 tablets
Nefmic Spas Tablet contains Mefenamic acid and Dicyclomine hydrochloride
Mefenamic acid
It is a NSAID which is used for the treatment of pain. It decreases the swelling in inflammation and also uterine contractions. It also inhibits PG synthesis.
Dicyclomine hydrochloride
It is a anticholinergic agent (acts against the action of acetycholine) and produces antispasmodic action.
- Muscle seizures an spasm
- Intestinal hyper motility
- Gastrointestinal spasm
- In treatment of mild to moderate pain
Mefenamic acid
It produces its pharmacological action by binding to prostaglandin synthetase receptors COX-1 and COX-2 and causes the inhibition of its action. As these plays a major role in causing inflammation.
Dicyclomine hydrochloride
The drug produces its dual action by direct action on smooth muscle and anti-muscuranic action.
Mefenamic acid
Absorption
It is rapidly absorbed after oral administration. The mean peak levels of mefenamic acid are ranging from 10-20mcg/ml3. Co-administration of mefenamic with antacid increases the absorption rate of magnesium hydroxide.
Distribution
It is well distributed in the body with 90% of the drug is bound to plasma protein. The volume of distribution of the drug is 1.06 l/kg. It is metabolized by liver cytochrome P450 enzyme CYP2C9 to 3-hydroxymethyl mefenamic acid (Metabolite I).
Excretion
About 52% of the drug is excreted in urine as glucuronides of mefenamic acid. About 20% of the drug is excreted through urine.
Dicyclomine hydrochloride
Absorption
The drug is administered orally with volume of distribution of 3.65/ L. About 99% of the drug is bound to plasma protein.
Excretion
About 79.5 % of the drug i excreted through urine and few amount is also excreted through feces.
- Mefenamic acid should not be administered to the patients with asthma, urticaria or allergic reactions
- Liver Problems
- Kidney Disease
- Blockage of Urinary Bladder
- Urinary Tract Blockage
- Enlarged Prostate
- Allergic Patients
- Patient with any sort of surgery
