Nefmic Spas Tablet2018-11-11T17:59:02+00:00
nefmic spas-soltech-product

Mefanamic acid   –  250 mg

Dicyclomine Hydrochloride  –  10 mg

Each box contain 10 Blister strips of 10 tablets

Nefmic Spas Tablet contains Mefenamic acid and Dicyclomine hydrochloride

Mefenamic acid

It is a NSAID which is used for the treatment of pain. It decreases the swelling in inflammation and also uterine contractions. It also inhibits PG synthesis. 

Dicyclomine hydrochloride

It is a anticholinergic agent (acts against the action of acetycholine) and produces antispasmodic action.

  • Muscle seizures an spasm
  • Intestinal hyper motility
  • Gastrointestinal spasm
  • In treatment of mild to moderate pain

Mefenamic acid

It produces its pharmacological action by binding to prostaglandin synthetase receptors COX-1 and COX-2 and causes the inhibition of its action.  As these plays a major role in causing inflammation.

Dicyclomine hydrochloride

The drug produces its dual action by direct action on smooth muscle and anti-muscuranic action.

Mefenamic acid

Absorption

It is rapidly absorbed after oral administration. The mean peak levels of mefenamic acid are ranging from 10-20mcg/ml3. Co-administration of mefenamic with antacid increases the absorption rate of magnesium hydroxide.

Distribution

 It is well distributed in the body with 90% of the drug is bound to plasma protein. The volume of distribution of the drug is 1.06 l/kg. It is metabolized by liver cytochrome P450 enzyme CYP2C9 to 3-hydroxymethyl mefenamic acid (Metabolite I).

Excretion

About 52% of the drug is excreted in urine as glucuronides of mefenamic acid. About 20% of the drug is excreted through urine.

 

Dicyclomine hydrochloride

Absorption

The drug is administered orally with volume of distribution of 3.65/ L. About 99% of the drug is bound to plasma protein.

Excretion

About 79.5 % of the drug i excreted through urine and few amount is also excreted through feces.

  • Mefenamic acid should not be administered to the patients with asthma, urticaria or allergic reactions
  • Liver Problems
  • Kidney Disease
  • Blockage of Urinary Bladder
  • Urinary Tract Blockage
  • Enlarged Prostate
  • Allergic Patients
  • Patient with any sort of surgery