Amoxycillin – 200 mg
Clavulanate Potassium – 28.5 mg
Each 30 ml With sterile Water & 6 Dose Cups
Avox dry syrup contains amoxicillin and clavulanic acid. Avox is an oral antibiotic in which amoxicillin is a beta-lactamase inhibitor and clavulanate potassium is potassium salt of clavulanic acid. Amoxicillin is an analog of ampicillin and it is derived from penicillin nucleus. Clavulanic acid is a beta lactum which is structurally related to penicillin and it has the ability to inactivate some of the beta lactase by causing blocking of the active site of these enzymes.
- Susceptible bacterial infections
- Lower respiratory tract infections
- Acute bacterial otitis media
- Skin and skin structure infections
- Urinary tract infections
Amoxicillin produces its action by binding to penicillin binding protein 1A which is present in the bacterial cell wall. Penicillin acylate the penicillin-sensitive transpepetidase C-terminal domain by opening the lactum ring. This causes inactivation of the enzyme which averts the formation of cross-link of two linear peptidoglycon strands. This inhibits the bacterila cell wall synthesis.
It causes irreversibly inhibition of beta lactamse and causes restauration of the antimicrobial activity of beta-lactam antibiotics against lactamase-secreting-resistant bacteria
The drug after oral administration is rapidly absorbed
About 20% of the drug is bound to plasma protein. The drug follows hepatic metabolism.
The drug is excreted in unchanged form in urine.
After oral administration the drug is 75% absorbed in the body.
About 22 to 30% of the drug is bound to plasma protein. The metabolism of the drug is through liver.
The drug is excreted through urine
- In patients with the history of hypersensitivity reaction
- Patient with the history of cholestatic jaundice
- Hepatic dysfunction related to the drug
- Hypersensitive reactions
- Hepatic dysfunction
- Clostridium difficile associated diarrhea (CDAD)
- Erythematous skin rashes
- In absence of suspected infection can cause drug resistance bacteria