Oxav Dry Syrup2018-11-13T20:31:01+00:00
oxav-soltech-product

Amoxycillin      –    200 mg

Clavulanate  Potassium     –    28.5 mg

Each 30 ml With sterile Water & 6 Dose Cups

Avox dry syrup contains amoxicillin and clavulanic acid. Avox is an oral antibiotic in which amoxicillin is a beta-lactamase inhibitor and clavulanate potassium is potassium salt of clavulanic acid. Amoxicillin is an analog of ampicillin and it is derived from penicillin nucleus. Clavulanic acid is a beta lactum which is structurally related to penicillin and it has the ability to inactivate some of the beta lactase by causing blocking of the active site of these enzymes.

  • Susceptible bacterial infections
  • Lower respiratory tract infections
  • Acute bacterial otitis media
  • Sinusitis
  • Skin and skin structure infections
  • Urinary tract infections

Amoxicillin

Amoxicillin produces its action by binding to penicillin binding protein 1A which is present in the bacterial cell wall. Penicillin acylate the penicillin-sensitive transpepetidase C-terminal domain by opening the lactum ring. This causes inactivation of the enzyme which averts the formation of cross-link of two linear peptidoglycon strands. This inhibits the bacterila cell wall synthesis.

Clavulanic acid

It causes irreversibly inhibition of beta lactamse and causes restauration of the antimicrobial activity of beta-lactam antibiotics against lactamase-secreting-resistant bacteria

Amoxicillin

Absorption

The drug after oral administration is rapidly absorbed

Distribution

About 20% of the drug is bound to plasma protein. The drug follows hepatic metabolism.

Excretion

The drug is excreted in unchanged form in urine. 

 

Clavulanate potassium

Absorption

After oral administration the drug is 75% absorbed in the body.

Distribution

About 22 to 30% of the drug is bound to plasma protein. The metabolism of the drug is through liver.

Excretion

The drug is excreted through urine

  • In patients with the history of hypersensitivity reaction
  • Patient with the history of cholestatic jaundice
  • Hepatic dysfunction related to the drug
  • Hypersensitive reactions
  • Hepatic dysfunction
  • Clostridium difficile associated diarrhea (CDAD)
  • Erythematous skin rashes
  • In absence of suspected infection can cause drug resistance bacteria