Razoba- LS Capsules2018-11-13T13:18:32+00:00
razoba ls-soltech-product

Rabeprazole Sodium     –      20 mg

 Levosulpride     –     75 mg

Each box contain 10 Alu-Alu strips of 10 tablets

Razoba- LS is a combination of rabeprazole and levosulpiride.

Rabeprazole

It is a proton pump inhibitor which inhibits the secretion of gastric acid. It belongs to the same class as that of omeprazole.  

Levosulpiride

It is a benzamide class of antipsychotic drug. It is mainly used for the treatment of psychosis and major depressive disorder. Levosulpiride is levo-isomer.

  • Short term treatment for erosion of stomach
  • Ulceration of esophagus caused by GERD
  • Maintenance therapy for long term use after initial response
  • In treatment with H. pylori infections
  • Chronic gastritis
  • Irritable bowel disease
  • Healing of duodenal ulcer

Rabeprazole

It is PPI which suppresses the gastric acid production. It acts by suppressing the final step in gastric acid formation. It produces dose related response. 

 

Levosulpiride

It acts as D2 receptor antagonist. It is a moderate antagonist at 5HT receptor. This property enhances its therapeutics efficacy in gastrointestinal disorder. This property with D2 receptor antagonism contributes its GI pk effect.

Rabeprazole

Absorption

After oral administration it is well absorbed in the body. 

Distribution

 The drug is metabolized by the liver with Cmax about 2.5mcg/ml. the peak concentration of the drug is about 2.5hrs. The apparent volume of distribution is 11.0-23.6 L.

Excretion

About 18% of the drug is excreted in feces through biliary excretion.

 

Levosulpiride

Absorption

It is well absorbed in the body with oral bioavailability about 30% with peak plasma concentration achieving in 3hrs.

Excretion

The drug is excreted through urine with plasma half life 4.3hr.

  • The drug overdose cannot be removed
  • Limb splay
  • Lateral position
  • Absence of ear reflex
  • Tremor
  • Hypersensitivity to the formulation ingredient
  • Pregnant and breast feeding mothers
  • Atrophic gastritis
  • Acute intestinal nephritis
  • Long treatment with acid suppressants can cause cyanocobalamin deficiency
  • Clostridium difficile associated diarrhea
  •  Increased risk of osteoporosis
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