Dextromethorphan Hydrobromide   –  10 mg

Phenylephrine hydrochloride  –   5 mg

Cetrizine hydrochloride   –   5 mg

Menthol    –   1.5 mg

100/60 ml

Mucorex DX syrup contains dextromethorphan hydrobromide, cetirizine and phenylephrine hydrochloride and menthol.

Dextromethorphan hydrobromide belongs to morphine class of drug. It is cough suppressant or anti-tussive drug which possesses sedative and dissociative properties.

Cetirizine is a second generation antihistamine. It is mainly used for the treatment of hay fever, angioedema or urticaria.

Phenylephrine hydrochloride is a direct acting sympathomimetic agent.

Menthol is an organic compound which is obtained from cornmint or mint oil. It is a local anesthetic used to relieve minor throat irritation.

• Common cold or flu
• Breathing illnesses (such as sinusitis, bronchitis)
• Help in relief in watery eyes, itchy eyes/nose/throat
• Allergies
• Rhinovirus infection
• Kimura’s diseases
• Chronic urticaria

Phenylephrine is a powerful vasoconstrictor and produces local and systematic action on by acting on α₁-adrenergic receptors peripheral vascular smooth muscle.

Cetirizine

It competes with histamine for binding at H1 receptor on the effectors cell surface which causes the suppression histaminic edema and pruritus. The low incidence of sedation is because the reduced penetration of cetirizine into CNS.

Dextromethorphan hydrobromide

It is an opioid like drug which produces its action by binding to NMDA glutamatergic receptors. It also targets serotonin reuptake pump by acting as alpha3/beta4 nicotinic receptor antagonist.

Cetirizine

Absorption

It is well absorbed in the body with mean peak plasma concentration (Cmax) of 114 ng/mL at a time (Tmax) of 2.2 hours

Distribution

It is well distributed in the body with 93% plasma protein binding. Vd is 0.41kg

Excretion

 The plasma half life is 7.9 ± 1.9 hours; total body clearance is 0.63 ml/min/kg

Phenylephrine

Absorption

It is absorbed after oral administration with reduced bioavailability about 38%. It follows first pass metabolism with peak serum concentration of 0.75-2 hours.

Distribution

The protein binding of the drug is about 95%

Excretion

Phenylephrine and its metabolites are excreted in urine

Dextromethorphan Hydrobromide

Absorption

After administration it gets well absorbed in the body from gastrointestinal tract and it exerts pharmacological effects in 15-30 minutes. The duration of action is 3-6 hrs.

Distribution

It is metabolized primarily by liver enzyme undergoing O-demethylation, N- demethylation, and partial conjugation with glucuronic acid and sulfate.

Excretion

The un-metabolized drug is excreted in urine.

• Patients with hypersensitivity to such drugs
• Renal disease
• Pediatric patients with renal impairment
• Hypersensitivity to any of the product
• Patients with hypersensitivity to such drugs

• Patients with predisposing factors of urinary retention
• Long treatment can cause  somnolence, fatigue, and asthenia
• Patient should not involved in those task which require complete concentration
• Patients with predisposing factors of urinary retention
• Dextromethorphan should not be used in pediatric patients
• Dextromethorphan should be cautiously used in the patients with bone marrow depression.