Camylofin dihydrochloride – 25 mg
Paracetamol – 325 mg
Each box contain 10 Blister strips of 10 tablets
Spascam is a combination of Camylofin dihydrochloride and paracetamol.
Camylofin dihydrochloride is a smooth muscle relaxant, produces its action by directly acting on smooth muscle and anticholinergic action by restricting the binding of acetlycholine to muscuranic receptor. It also causes inihibition of phosphodiasterase type IV which causes increase in cyclic AMP and reduces cystolic calcium which relieves muscle spasm.
Paracetamol is also known as acetaminophen and is widely used as over the counter analgesic and anti-pyretic. It is a mild analgesic which causes relief in mild headaches and other aches and pains. In combination with other drugs like opioid analgesic, paracetamol is used in the management of post surgical pain and severe pain.
- Abdominal cramps and pain
- Migraine
- Angina pectoris
- Dysmennorhoea
- Myocardial infarction
- Renal colic
- Spasticity
It causes it direct smooth muscle relaxant action by inhibiting the binding of acetylcholine to muscarinic receptors which increases the cyclic AMP and reduce the cystolic calcium and causes smooth muscle spasm.
Camylofin dihydrocholride produces direct action on smooth muscle and causes relieve in muscle spasm.
Paracetamol
Absorption
It has rapid and complete absorption
Distribution
The protein binding of the drug is about 25%, it undergoes glucuronidation in liver.
Excretion
About 80% of acetaminophen is excreted in the urine after conjugation and about 3% of the drug is excreted unchanged.
- Liver Failure
- Liver Problems
- Serious Kidney problems
- Glucoma
- Urinary retention
- Prostatic enlargement
- Tachycardia
- Cardiac insufficiency
- Paralytic ileus