Zolfa Syrup2018-11-13T13:56:43+05:30

Deflazacort – 6 mg/5ml

30ml/60ml With
Outer Carton

Eflaza syrup contains deflazacort. It is a glucocorticoid which is used as immunosuppressant and anti-inflammatory. It is an inactive prodrug which is metabolized rapidly to active drug as 21-desacetyldeflazacort. It reduces the inflammation in various diseases and inflammation.

  • In anti-inflammatory conditions
  • Immunosuppressant
  • In treatment of certaintype of leukaemia

Deflazacort produces its action by preventing the release of chemicals from the cell that are important for immune system. These chemicals  cause immune and allergic responses which causes inflammation. By decrease in the chemicals in that area causes reduced inflammation. Deflazacort causes decrease in the number of white blood cells present in the blood. As it also act as immunosuppressant to prevent rejection in organ transplantation.


After oral administration it is well absorbed and gets converted to plasma esterase which is a pharmacologically active metabolite. The drug achieves its peak concentration in 1.5 to 2hrs.


The drug after oral administration is 40% bound to plasma protein but the drug is having no affinity for corticosteroid binding globulin. In very low concentration, the drug has ability to cross blood brain barrier. After a long treatment the drug can be available in central nervous system. The drug plasma half life is 1.1 to 1.9hrs.


The drug is excreted from the body through kidney. About 70% of the drug is excreted through urine and 30% of the drug through feces.

  • Live virus vaccines in those receiving immunosuppressive doses
  • Systemic infection
  • Children with history of chicken pox, measles and shingles
  • Hypersensitivity reactions
  • Patients can produce increased risk of confusion, irritability, mood
  • changes or depression
  • Patients can also develop suicidal thoughts
  • Drug not to be used with the doctor’s consultation
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