Methylcobalamin – 1500 mcg

Pyridoxine  HCL  –  100 mg

Nicotinamide – 100 mg

Each box contain 5 Blister bottles of 2 ml

Methoba Plus is a combination of methylcobalamin, pydoxine hydrochloride, nicotinamide and benzyl alcohol.

Methylcobalamin is a form of vitaminB₁₂. It is a cobalamin which differs from cyanocobalamin. The cyanide group is replaced by methyl group in methylcobalamin. Octahedral cobalt III is present in the centre.  

• Megaloblastic anemia caused by vitB₁₂ deficiency
• Peripheral neuropathy
• Diabetic neuropathy
• Pernicious anemia
• Amyotrophic lateral sclerosis

Methycobalamin

It is the active form of vitamin B₁₂ which a water soluble vitamin. It functions as to transfer methyl group for the regeneration of methionine from homocysteine. It acts as a cofactor for enzyme methionin synthase. In cases of anemia it causes the production of erythrocytes by nucleic acid synthesis in bone marrow.  

Methycobalamin

Absorption

The drug is well absorbed in the body with peak concentration achieved after 3hrs.

Distribution

After oral administration it is well distributed

Excretion

The drug is excreted through urine.

• Decreases the GI absorption with neomycin
• Reduces the serum concentrations of oral contraceptives

• Polycythemia rubra vera
• Megaloblastic anemia
• Cobalt or cobalamin allergy
• Leber’s disease.