Each 5 ml contains:
Montelukast Sodium    –   4 mg
Levocetirizine     –    2.5 mg

30ml/60ml With Outer Carton

Monvent LC is a combination of montelukast sodium and levocetirizine. Montelukast sodium is a lukoterine receptor antagonist used for

the treatment of asthma and related symptoms.  It produces its action

by blocking the action of leukoterine D4 and cysteinyl leukoterine

receptors in lungs or bronchial tubes by binding to it.

Levocetrizine is a third generation non-sedative       anti-histamine. Levocetirizine is an active R-enantiomer of cetrizine. It mainly       causes blocking of histamine receptors and prevents the release of allergy chemicals released.

• Treating allergic symptoms
• Chronic hives
• Watery eyes, runny nose, itching eyes/nose, sneezing and itching
•  Urticaria

Montelukast sodium

It produces its action by selectively antagonizes leukoterine D4 (LTD4) at cysteinyl leukoterine receptor which is present in the body. By inhibiting the actions of CysLT1, it prevents the airway edema, smooth   muscle contraction and enhanced secretion of viscous and thick fluid.

Levocetirizine

It competes with histamine for binding at H1 receptor on the effectors cell surface which causes the suppression histaminic edema      and pruritus. The low incidence of sedation is because the reduced penetration of cetirizine into CNS.

Montelukast Sodium

Absorption

After oral administration it gets rapidly absorbed with 64% of the bioavailability.

Distribution

Nearly about 64% of the drug is absorbed after oral administration with 99% of the drug bound to plasma protein.  The drug follows hepatic metabolism.

Excretion

The drug is excreted through bile with elimination half life of 2.7-5.5 hrs. The clearance rate is 45mL/min in adults.

Levocetirizine

Absorption

It is well absorbed in the body with mean peak plasma concentration (Cmax) of 114ng/mL at a time (Tmax) of 2.2 hours

Distribution

It is well distributed in the body with 93% plasma protein binding. Vd is 0.41kg

Excretion

The plasma half life is 7.9 ± 1.9 hours; total body clearance is 0.63 ml/min/kg

• Prolong use can cause severe renal failure
• Enlarged Prostate with Urination Problems
• Hemodialysis with High-Flux Membrane
• Drowsiness
• Hallucination

• Prolong use can cause severe renal failure
• Enlarged Prostate with Urination Problems
• Hemodialysis with High-Flux Membrane
• Drowsiness
• Hallucination